LEAD-DBS rendering selected for coverart in NeuroImage

We are happy to share the current NeuroImage cover art with you, which shows a 3D rendering made with our toolbox (volume 107, 15 February 2015).

The accompanying text for the image is the following:

Depicted is a three-dimensional reconstruction of deep brain stimulation electrode placements in a patient suffering from Parkinson’s disease. Using a novel open-source toolbox that is introduced in this issue of NeuroImage, the electrodes are modeled in their accurate position in the brain based on postoperative magnetic resonance imaging and using the accurate dimensions of the electrode lead model implanted in the patient’s brain. 

Using such a reconstruction of the stimulation setting, it can be determined, whether deep brain stimulation electrodes are accurately placed within the target structure – in this case the sensorimotor functional zone of the subthalamic nucleus. Moreover, the volume of tissue activated by the stimulation can be modeled using the actual stimulation parameters applied in the patient’s treatment. 

Lastly, based on the volume of activated tissue that has been modeled for a certain patient, diffusion weighted imaging based fiber-tracking may be used to analyze the influence of the stimulation on the whole structural (and functional) connectome of the patient’s brain. This combined approach allows the researcher to study local effects of the stimulation (associated with the placement of the electrode within the target structure), as well as distant effects effects (associated with the whole-brain network influenced by the stimulation).

LEAD-DBS awarded with Max-Rubner-Prize of Stiftung Charité

We are happy to announce that LEAD-DBS was awarded with the Max-Rubner-Prize for Innovation and Technology of Stiftung Charité this January. Prize money will be used for further development and deployment of the toolbox.


Methodological toolbox paper accepted in NeuroImage

We are happy to announce that a methodological paper describing the toolbox in detail has been accepted in NeuroImage.

The publication can be found here.


The toolbox also received a SciRes/NIF/Nlx ID which can be provided when citing the toolbox: SciRes_000188.



LEAD-DBS presentation at “The Future of Deep Brain Stimulation”, Tuscony, Italy

A short presentation of the DBS-localization toolbox was possible at nsas summer school “The Future of Deep Brain Stimulation” in Cortona, Tuscany, Italy was possible and we gained great feedback for further improving the toolbox here. Many thanks go to the organizers of the workshop at this point. Foto by Tora Bonnevie.

The future of Deep Brain Stimulation 2014, Tuscany, Italy, Presentation at Summerschool

The future of Deep Brain Stimulation 2014, Tuscany, Italy, Presentation at Summerschool

First publication including LEAD-DBS analysis online

We are happy to announce that the first paper including an analysis with LEAD-DBS is online here

Barow, E., Neumann, W.-J., Brücke, C., Huebl, J., Horn, A., Brown, P., et al. (2014). Deep brain stimulation suppresses pallidal low frequency activity in patients with phasic dystonic movements. Brain : a Journal of Neurology, awu258. doi:10.1093/brain/awu258


New Interesting #DBS-Papers

Walkthrough Videos online

Today we added some walkthrough-videos to the website. These show the complete reconstruction procedure of the toolbox in seven easy steps.
We are also constantly working on updating the manual and added some screenshots to the site recently. For all other questions, please feel free to use the forum.

New Interesting #DBS-Papers

Poster-Presentation at OHBM 2014 in Hamburg

We were able to demonstrate our toolbox live at the poster-presentation of OHBM in Hamburg to interested visitors.


Lead-DBS @ OHBM Hackathon 2014 in Berlin

At OHBM Hackathon 2014 @ c-base Berlin, LEAD-DBS was presented to a wider audience for the first time. Together with Tarek Sherif from Montreal, an export function to the web-visualization software Brainbrowser was written, which makes it possible to view localization results on standard web-browsers.