Methodological publications
- Methodological toolbox publications
- Horn, A., Li, N., Dembek, T. A., Kappel, A., Boulay, C., Ewert, S., et al. (2018). Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging. NeuroImage.
- Horn A, Kühn AA (2015). Lead-DBS: A toolbox for deep brain stimulation electrode localizations and visualizations. NeuroImage.
- Horn, A., Kühn, A. A., Merkl, A., Shih, L., Alterman, R., & Fox, M. (2017). Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space. NeuroImage, 150, 395–404.
- Ewert, S., Plettig, P., Li, N., Chakravarty, M. M., Collins, D. L., Herrington, T. M., et al. (2017). Toward defining deep brain stimulation targets in MNI space: A subcortical atlas based on multimodal MRI, histology and structural connectivity. NeuroImage.
- Ewert, S., Horn, A., Finkel, F., Li, N., Kühn, A. A., & Herrington, T. M. (2018). Optimization and comparative evaluation of nonlinear deformation algorithms for atlas-based segmentation of DBS target nuclei. NeuroImage, 1–13.
- Husch, A., Petersen, M. V., Gemmar, P., Goncalves, J., & Hertel, F. (2017). PaCER – A fully automated method for electrode trajectory and contact reconstruction in deep brain stimulation. NeuroImage. Clinical, 17, 80–89.
- Dembek, T. A., Hoevels, M., Hellerbach, A., Horn, A., Petry-Schmelzer, J. N., Borggrefe, J., et al. (2019). Directional DBS leads show large deviations from their intended implantation orientation. Parkinsonism & Related Disorders.
- Treu, S., Strange, B., Oxenford, S., Kuehn, A., & Horn, A. (2020). Deep Brain Stimulation: Imaging on a group level, 142, 3086.
- SciRes-ID for the toolbox
- Lead Connectome methods publications
- Andreas Horn, Dirk Ostwald, Marco Reisert, and Felix Blankenburg (2013). The structural-functional connectome and the default mode network of the human brain. NeuroImage.
- Horn, A., & Blankenburg, F. (2016). Toward a standardized structural-functional group connectome in MNI space. NeuroImage, 124(Pt A), 310–322.
Cover Art
Applications of LEAD-DBS
2022
- Ganos C, Al-Fatly B, Fischer JF, Baldermann JC, Hennen C, Visser-Vandewalle V, Neudorfer C, Martino D, Li J, Bouwens T, Ackermanns L, Leentjens AFG, Pyatigorskaya N, Worbe Y, Fox MD, Kühn AA, Horn A. A neural network for tics: insights from causal brain lesions and deep brain stimulation. Brain.
- Bowren M, Bruss J, Manzel K, Edwards D, Liu C, Corbetta M, Tranel D, Boes AD. Post-stroke outcomes predicted from multivariate lesion-behaviour and lesion network mapping. Brain.
- Jana Peeters, Alexandra Boogers, Tine Van Bogaert, Hannah Davidoff, Robin Gransier, Jan Wouters, Bart Nuttin, Myles Mc Laughlin. Electrophysiologic Evidence That Directional Deep Brain Stimulation Activates Distinct Neural Circuits in Patients With Parkinson Disease. Neuromodulation: Technology at the Neural Interface.
- Yan H, Elkaim LM, Venetucci Gouveia F, Huber JF, Germann J, Loh A, Benedetti-Isaac JC, Doshi PK, Torres CV, Segar DJ, Elias GJB, Boutet A, Cosgrove GR, Fasano A, Lozano AM, Kulkarni AV, Ibrahim GM. Deep brain stimulation for extreme behaviors associated with autism spectrum disorder converges on a common pathway: a systematic review and connectomic analysis. J Neurosurg.
- Martje G. Pauly, Magdalena Barlage, Feline Hamami, Julia Steinhardt, Julianne Baarbé, Stephanie Tran, Henrike Hanssen, Rebecca Herzog, Vera Tadic, Norbert Brüggemann, Robert Chen, Alexander Münchau, Tobias Bäumer, Anne Weissbach. Subthalamic nucleus conditioning reduces premotor-motor interaction in Parkinson’s disease. Parkinsonism & Related Disorders.
- Muthuraman Muthuraman, Marcell Palotai, Borbála Jávor-Duray, Andrea Kelemen, Nabin Koirala, László Halász, Loránd Erőss, Gábor Fekete, László Bognár, Günther Deuschl, Gertrúd Tamás. Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease. NeuroImage: Clinical.
- Baraniuk JN, Amar A, Pepermitwala H, Washington SD. Differential Effects of Exercise on fMRI of the Midbrain Ascending Arousal Network Nuclei in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) in a Model of Postexertional Malaise (PEM). Brain Sci.
- Yu, K., Ren, Z., Hu, Y. et al. Efficacy of caudal pedunculopontine nucleus stimulation on postural instability and gait disorders in Parkinson’s disease. Acta Neurochir.
2021
- Germann, Jurgen & Elias, Gavin & Boutet, Alexandre & Neudorfer, Clemens & Horn, Andreas & Loh, Aaron. (2021). Brain structures and networks responsible for stimulation-induced memory flashbacks during forniceal deep brain stimulation for Alzheimer’s disease. Alzheimer’s & dementia: the journal of the Alzheimer’s Association.
- Clayton P. Mosher, Adam N. Mamelak, Mahsa Malekmohammadi, Nader Pouratian, Ueli Rutishauser, Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation, Neuron, 2021.
- Li, N., Hollunder, B., Baldermann, J. C., Kibleur, A., Treu, S., Akram, H., Al-Fatly, B., Strange, B. A., Barcia, J. A., Zrinzo, L., Joyce, E. M., Chabardes, S., Visser-Vandewalle, V., Polosan, M., Kuhn, J., Kühn, A. A., & Horn, A. (n.d.). A Unified Functional Network Target for Deep Brain Stimulation in Obsessive-Compulsive Disorder. Biological Psychiatry
- Baldermann J.C., Schüller T., Kohl S., Voon V., Li N., Hollunder B., Figee M., Haber S.N, Sheth S.A, Mosley P.E, Huys D., Johnson K.A, Butson C., Ackermans L., van der Vlis T.B., Leentjens A.F.G, Barbe M., Visser-Vandewalle V., Kuhn J. & Horn A., Connectomic deep brain stimulation for obsessive-compulsive disorder, Biological Psychiatry.
- Robert S. Eisinger, Jackson N. Cagle, Jose Alcantara, Enrico Opri, Stephanie Cernera, Anh Le, Elena M. Torres Ponce, Joseph Lanese, Brawn Nelson, Janine Lopes, Christopher Hundley, Tasmeah Ravy, Samuel S. Wu, Kelly D. Foote, Michael S. Okun, Aysegul Gunduz (2021). Distinct roles of the human subthalamic nucleus and dorsal pallidum in Parkinson’s disease impulsivity. Biological Psychiatry.
- Leon Sobesky, Lukas L Goede, Vincent J J Odekerken, Qiang Wang, Ningfei Li, Clemens Neudorfer, Nanditha Rajamani, Bassam Al-Fatly, Martin Reich, Jens Volkmann, Rob M A de Bie, Andrea A Kühn, Andreas Horn, Subthalamic and pallidal deep brain stimulation: are we modulating the same network?, Brain.
- Clemens Neudorfer, Gavin J B Elias, Martin Jakobs, Alexandre Boutet, Jürgen Germann, Keshav Narang, Aaron Loh, Michelle Paff, Andreas Horn, Walter Kucharczyk, Wissam Deeb, Bryan Salvato, Leonardo Almeida, Kelly D Foote, Paul B Rosenberg, David F Tang-Wai, William S Anderson, Zoltan Mari, Francisco A Ponce, David A Wolk, Anna D Burke, Stephen Salloway, Marwan N Sabbagh, M Mallar Chakravarty, Gwenn S Smith, Constantine G Lyketsos, Michael S Okun, Andres M Lozano, Mapping autonomic, mood, and cognitive effects of hypothalamic region deep brain stimulation, Brain.
- Gavin J. B. Elias, Jürgen Germann, Alexandre Boutet, Aaron Loh, Bryan Li, Aditya Pancholi, Michelle E. Beyn, Asma Naheed, Nicole Bennett, Jessica Pinto, Venkat Bhat, Peter Giacobbe, D. Blake Woodside, Sidney H. Kennedy, Andres M. Lozano, 3 T MRI of rapid brain activity changes driven by subcallosal cingulate deep brain stimulation, Brain.
- Jürgen Germann, Gavin J B Elias, Clemens Neudorfer, Alexandre Boutet, Clement T Chow, Emily H Y Wong, Roohie Parmar, Flavia Venetucci Gouveia, Aaron Loh, Peter Giacobbe, Se Joo Kim, Hyun Ho Jung, Venkat Bhat, Walter Kucharczyk, Jin Woo Chang, Andres M Lozano, Potential optimization of focused ultrasound capsulotomy for obsessive compulsive disorder, Brain.
- Oswal, A., Gratwicke, J., Akram, H., Jahanshahi, M., Zaborszky, L., Brown, P., Hariz, M., Zrinzo, L., Foltynie, T., & Litvak, V. (2021). Cortical connectivity of the nucleus basalis of Meynert in Parkinson’s disease and Lewy body dementias. Brain.
- Ashley L B Raghu, John Eraifej, Nagaraja Sarangmat, John Stein, James J FitzGerald, Stephen Payne, Tipu Z Aziz, Alexander L Green, Pallido-putaminal connectivity predicts outcomes of deep brain stimulation for cervical dystonia, Brain.
- Siddiqi, S.H., Schaper, F.L.W.V.J., Horn, A. et al. Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease. Nat Hum Behav
- Alexandre Boutet, Jurgen Germann, Dave Gwun, Aaron Loh, Gavin J B Elias, Clemens Neudorfer, Michelle Paff, Andreas Horn, Andrea A Kuhn, Renato P Munhoz, Suneil K Kalia, Mojgan Hodaie, Walter Kucharczyk, Alfonso Fasano, Andres M Lozano (2021). Sign-specific stimulation ‘hot’ and ‘cold’ spots in Parkinson’s disease validated with machine learning, Brain Communications.
- He, S., Baig, F., Mostofi, A., Pogosyan, A., Debarros, J., Green, A.L., Aziz, T.Z., Pereira, E., Brown, P. and Tan, H. (2021), Closed‐Loop Deep Brain Stimulation for Essential Tremor Based on Thalamic Local Field Potentials. Mov Disord.
- Zhang, C., Lai, Y., Li, J., He, N., Liu, Y., Li, Y., Li, H., Wei, H., Yan, F., Horn, A., Li, D. and Sun, B. (2021), Subthalamic and pallidal stimulations in patients with Parkinson’s disease: common and dissociable connections. Ann Neurol.
- He S Baig F Mostofi A Pogosyan A Debarros J Green AL Aziz TZ Pereira EA Brown P Tan H. (2021). Closed-Loop Deep Brain Stimulation for Essential Tremor Based on Thalamic Local Field Potentials. Mov Disord.
- Sasikumar, S., Cohn, M., Harmsen, I.E., Loh, A., Cho, S.S., Sáenz-Farret, M., Maciel, R., Soh, D., Boutet, A., Germann, J., Elias, G., Youm, A., Duncan, K., Rowland, N.C., Strafella, A.P., Kalia, S.K., Lozano, A.M. and Fasano, A. (2021), Single-Trajectory Multiple-Target Deep Brain Stimulation for Parkinsonian Mobility and Cognition. Mov Disord.
- , et al. (2021). Probabilistic characterisation of deep brain stimulation in patients with tardive syndromes.
- Lai, Yijie & Song, Yunhai & Su, Daoqing & Wang, Linbin & Zhang, ChenCheng & Sun, Bomin & Nonnekes, Jorik & Bloem, Bas & Li, Dianyou. (2021). Pallidal stimulation as treatment for camptocormia in Parkinson’s disease. npj Parkinson’s Disease. 7.
- Juan Carlos Baldermann, Jens Kuhn, Thomas Schüller, Sina Kohl, Pablo Andrade, Sophia Schleyken, Reinhild Prinz-Langenohl, Martin Hellmich, Michael T. Barbe, Lars Timmermann, Veerle Visser-Vandewalle, Daniel Huys. Thalamic deep brain stimulation for Tourette Syndrome: A naturalistic trial with brief randomized, double-blinded sham-controlled periods. Brain Stimulation.
- Darrin J. Lee, Neil M. Drummond, Utpal Saha, Philippe De Vloo, Robert F. Dallapiazza, Robert Gramer, Tameem M. Al-Ozzi, Jordan Lam, Aaron Loh, Gavin J.B. Elias, Alexandre Boutet, Jurgen Germann, Mojgan Hodaie, Alfonso Fasano, Renato P. Munhoz, William Hutchison, Melanie Cohn, Robert Chen, Suneil K. Kalia, Andres M. Lozano.(2021) Acute low frequency dorsal subthalamic nucleus stimulation improves verbal fluency in Parkinson’s disease. Brain Stimulation, 14, 4:754-760
- Tian, H., Zhang, B., Yu, Y., Zhen, X., Zhang, L., Yuan, Y., & Wang, L. (2021). Electrophysiological signatures predict clinical outcomes after deep brain stimulation of the globus pallidus internus in Meige syndrome. Brain Stimulation.
- Treu, S., Gonzalez-Rosa, J. J., Soto-Leon, V., Lozano-Soldevilla, D., Oliviero, A., Lopez-Sosa, F., Reneses-Prieto, B., Barcia, J. A., & Strange, B. A. (2021). A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation. Brain Stimulation.
- Flavia Venetucci Gouveia, Jürgen Germann, Gavin JB. Elias, Clement Hamani, Erich Talamoni Fonoff, Raquel Chacon Ruiz Martinez, Case report: 5 Years follow-up on posterior hypothalamus deep brain stimulation for intractable aggressive behaviour associated with drug-resistant epilepsy. Brain Stimulation.
- Andrew H. Smith, Ki Sueng Choi, Allison C. Waters, Amy Aloysi, Helen S. Mayberg, Brian H. Kopell, Martijn Figee. Replicable effects of deep brain stimulation for obsessive-compulsive disorder. Brain Stimulation.
- Khaled Moussawi, Min Jae Kim, Sydney Baybayan, Myles Wood, Kelly A. Mills. Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson’s disease. Brain Stimulation.
- Huang Y, Sun B, Debarros J, Zhang C, Zhan S, Li D, Zhang C, Wang T, Huang P, Lai Y, Brown P, Cao C, Tan H. Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients. Elife.
- He S, Deli A, Fischer P, Wiest C, Huang Y, Martin S, Khawaldeh S, Aziz TZ, Green AL, Brown P, Tan H. Gait-Phase Modulates Alpha and Beta Oscillations in the Pedunculopontine Nucleus. J Neurosci.
- Salvatore Bertino, Gianpaolo Antonio Basile, Alessia Bramanti, Rosella Ciurleo, Adriana Tisano, Giuseppe Pio Anastasi, Demetrio Milardi, Alberto Cacciola. Ventral intermediate nucleus structural connectivity-derived segmentation: anatomical reliability and variability. NeuroImage.
- Zhang, S., Cao, C., Quinn, A., Vivekananda, U., Zhan, S., Liu, W., Sun, B., Woolrich, M., Lu, Q., & Litvak, V. (2021). Dynamic Analysis on Simultaneous iEEG-MEG Data via Hidden Markov Model. NeuroImage.
- Diaz, C., Gonzalez-Escamilla, G., Ciolac, D., García, M., Rivas, P., G Sola, R., Barbosa, A., Pastor, J., Vega Zelaya, L., & Groppa, S. (2021). Network Substrates of Centromedian Nucleus Deep Brain Stimulation in Generalized Pharmacoresistant Epilepsy. Neurotherapeutics.
- Kakusa, B., Huang, Y., Barbosa, D., Feng, A., Gattas, S., Shivacharan, R., Lee, E., Kuijper, F., Saluja, S., Parker, J., Miller, K., Keller, C., Bohon, C., & Halpern, C. (2021). Anticipatory human subthalamic area beta-band power responses to dissociable tastes correlate with weight gain. Neurobiology of Disease.
- Fernando Lopez-Sosa, Blanca Reneses, Florencia Sanmartino, Ana Galarza Vallejo, Julia Garcia-Albea, Alvaro J Cruz-Gomez, Mar Yebra, Antonio Oliviero, Juan A Barcia, Bryan A Strange, Javier J Gonzalez-Rosa, Nucleus Accumbens Stimulation Modulates Inhibitory Control by Right Prefrontal Cortex Activation in Obsessive-Compulsive Disorder (2021). Cerebral Cortex.
- Erik H Middlebrooks, MD, Ayushi Jain, MBBS, Lela Okromelidze, MD, Chen Lin, PhD, Erin M Westerhold, RT(R)(MR), Chad A O’Steen, RT(R)(MR), Anthony L Ritaccio, MD, Alfredo Quiñones-Hinojosa, MD, William O Tatum, DO, Sanjeet S Grewal, MD, Acute Brain Activation Patterns of High- Versus Low-Frequency Stimulation of the Anterior Nucleus of the Thalamus During Deep Brain Stimulation for Epilepsy, Neurosurgery.
- Morishita, T., Sakai, Y., Iida, H., Yoshimura, S., Ishii, A., Fujioka, S., Tanaka, S. C., & Inoue, T. (2021). Neuroanatomical considerations for optimizing thalamic deep brain stimulation in Tourette syndrome, Journal of Neurosurgery.
- Bina Kakusa, Sabir Saluja, Daniel A.N. Barbosa, Sam Cartmell, Flint M. Espil, Nolan R. Williams, Jennifer A. McNab, Casey H. Halpern (2021). Evidence for the role of the dorsal ventral lateral posterior thalamic nucleus connectivity in deep brain stimulation for Gilles de la Tourette syndrome. Journal of Psychiatric Research.
- Wenzel GR, Roediger J, Brücke C, Marcelino ALA, Gülke E, Pötter-Nerger M, Scholtes H, Wynants K, Juárez Paz LM, Kühn AA. CLOVER-DBS: Algorithm-Guided Deep Brain Stimulation-Programming Based on External Sensor Feedback Evaluated in a Prospective, Randomized, Crossover, Double-Blind, Two-Center Study. J Parkinsons Dis.
- Seung Hyun Lee, Jooyoung Lee, Mi Sun Kim, Yun Su Hwang, Sungyang Jo, Kye Won Park, Sang Ryong Jeon, Sun Ju Chung. Factors correlated with therapeutic effects of globus pallidus deep brain stimulation on freezing of gait in advanced Parkinson’s disease: A pilot study. Parkinsonism & Related Disorders.
- Lee SH, Lee J, Kim MS, Hwang YS, Jo S, Park KW, Jeon SR, Chung SJ. Factors correlated with therapeutic effects of globus pallidus deep brain stimulation on freezing of gait in advanced Parkinson’s disease: A pilot study. Parkinsonism Relat Disord.
- Erik H. Middlebrooks, Lela Okromelidze, Joshua K. Wong, Robert S. Eisinger, Mathew R. Burns, Ayushi Jain, Hsin-Pin Lin, Jun Yu, Enrico Opri, Andreas Horn, Lukas L. Goede, Kelly D. Foote, Michael S. Okun, Alfredo Quiñones-Hinojosa, Ryan J. Uitti, Sanjeet S. Grewal, Takashi Tsuboi. Connectivity correlates to predict essential tremor deep brain stimulation outcome: Evidence for a common treatment pathway. NeuroImage: Clinical.
- Hannah H. Riskin-Jones, Alon Kashanian, Hiro Sparks, Evangelia Tsolaki, Nader Pouratian (2021). Increased structural connectivity of thalamic stimulation sites to motor cortex relates to tremor suppression, NeuroImage: Clinical.
- Jean-Philippe Lévy, T.A. Khoa Nguyen, Lenard Lachenmayer, Ines Debove, Gerd Tinkhauser, Katrin Petermann, Alba Segura Amil, Joan Michelis, Michael Schüpbach, Andreas Nowacki, Claudio Pollo. Structure-function relationship of the posterior subthalamic area with directional deep brain stimulation for essential tremor. NeuroImage: Clinical.
- Muthuraman Muthuraman, Marcell Palotai, Borbála Jávor-Duray, Andrea Kelemen, Nabin Koirala, László Halász, Loránd Erőss, Gábor Fekete, László Bognár, Günther Deuschl, Gertrúd Tamás. Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease. NeuroImage: Clinical.
- Dembek, T.A., Baldermann, J.C., Petry‐Schmelzer, J.‐N., Jergas, H., Treuer, H., Visser‐Vandewalle, V., Dafsari, H.S. and Barbe, M.T. (2021), Sweetspot Mapping in Deep Brain Stimulation: Strengths and Limitations of Current Approaches. Neuromodulation: Technology at the Neural Interface.
- Sildatke E, Gruendler TOJ, Ullsperger M, Dembek TA, Baldermann JC, Kohl S, Visser-Vandewalle V, Huys D, Kuhn J, Schüller T. Deep Brain Stimulation Reduces Conflict-Related Theta and Error-Related Negativity in Patients With Obsessive-Compulsive Disorder. Neuromodulation.
- van der Vlis, T.A.B., Ackermans, L., Mulders, A.E., Vrij, C.A., Schruers, K., Temel, Y., Duits, A. and Leentjens, A.F. (2021), Ventral Capsule/Ventral Striatum Stimulation in Obsessive‐Compulsive Disorder: Toward a Unified Connectomic Target for Deep Brain Stimulation?. Neuromodulation: Technology at the Neural Interface.
- Bargiotas, P., Nguyen, T.A.K., Bracht, T., Mürset, M., Nowacki, A., Debove, I., Muellner, J., Michelis, J.P., Pollo, C., Schüpbach, W.M.M. and Lachenmayer, M.L. (2021), Long‐Term Outcome and Neuroimaging of Deep Brain Stimulation in Holmes Tremor: A Case Series. Neuromodulation: Technology at the Neural Interface.
- Gadot Ron, Shofty Ben, Najera Ricardo A., Anand Adrish, Banks Garrett, Khan Abdul Basit, LoPresti Melissa A., Vanegas Arroyave Nora, Sheth Sameer A. Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder. Frontiers in Neuroscience.
- Sammartino F, Taylor P, Chen G, Reynolds RC, Glen D and Krishna V (2021) Functional Neuroimaging During Asleep DBS Surgery: A Proof of Concept Study. Front. Neurol.
