Publications

Methodological publications

• Methodological toolbox publications
  • Horn, A., Li, N., Dembek, T. A., Kappel, A., Boulay, C., Ewert, S., et al. (2018). Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging. NeuroImage.
  • Horn A, Kühn AA (2015). Lead-DBS: A toolbox for deep brain stimulation electrode localizations and visualizations. NeuroImage.
  • Horn, A., Kühn, A. A., Merkl, A., Shih, L., Alterman, R., & Fox, M. (2017). Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space. NeuroImage, 150, 395–404.
  • Ewert, S., Plettig, P., Li, N., Chakravarty, M. M., Collins, D. L., Herrington, T. M., et al. (2017). Toward defining deep brain stimulation targets in MNI space: A subcortical atlas based on multimodal MRI, histology and structural connectivity. NeuroImage.
  • Ewert, S., Horn, A., Finkel, F., Li, N., Kühn, A. A., & Herrington, T. M. (2018). Optimization and comparative evaluation of nonlinear deformation algorithms for atlas-based segmentation of DBS target nuclei. NeuroImage, 1–13.
  • Husch, A., Petersen, M. V., Gemmar, P., Goncalves, J., & Hertel, F. (2017). PaCER – A fully automated method for electrode trajectory and contact reconstruction in deep brain stimulation. NeuroImage. Clinical, 17, 80–89.
  • Dembek, T. A., Hoevels, M., Hellerbach, A., Horn, A., Petry-Schmelzer, J. N., Borggrefe, J., et al. (2019). Directional DBS leads show large deviations from their intended implantation orientation. Parkinsonism & Related Disorders.
  • Treu, S., Strange, B., Oxenford, S., Kuehn, A., & Horn, A. (2020). Deep Brain Stimulation: Imaging on a group level, 142, 3086.
• SciRes-ID for the toolbox
  • SciRes_000188
• Lead Connectome methods publications
  • Andreas Horn, Dirk Ostwald, Marco Reisert, and Felix Blankenburg (2013). The structural-functional connectome and the default mode network of the human brain. NeuroImage.
  • Horn, A., & Blankenburg, F. (2016). Toward a standardized structural-functional group connectome in MNI space. NeuroImage, 124(Pt A), 310–322.

Cover Art

Applications of LEAD-DBS

2020

• Li, N., Baldermann, J.C., Kibleur, A., Treu, S., Akram, H., Elias, G.J.B., Boutet, A., Lozano, A.M., Al-Fatly, B., Strange, B., Barcia, J.A., Zrinzo, L., Joyce, E., Chabardes, S., Visser-Vandewalle, V., Polosan, M., Kuhn, J., Kühn, A.A., Horn, A., 2020. A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder. Nat. Commun. 11, 3364.
• Horn, A., Fox, M.D., 2020. Opportunities of Connectomic Neuromodulation. Neuroimage 117180.
• Kara A Johnson, Gordon Duffley, Daria Nesterovich Anderson, Jill L Ostrem, Marie-Laure Welter, Juan Carlos Baldermann, Jens Kuhn, Daniel Huys, Veerle Visser-Vandewalle, Thomas Foltynie, Ludvic Zrinzo, Marwan Hariz, Albert F G Leentjens, Alon Y Mogilner, Michael H Pourfar, Leonardo Almeida, Aysegul Gunduz, Kelly D Foote, Michael S Okun, Christopher R Butson, Structural connectivity predicts clinical outcomes of deep brain stimulation for Tourette syndrome, Brain, , awaa188
• Khawaldeh, S., Tinkhauser, G., Shah, S.A., Peterman, K., Debove, I., Nguyen, T.A.K., Nowacki, A., Lachenmayer, M.L., Schuepbach, M., Pollo, C., Krack, P., Woolrich, M., Brown, P., 2020. Subthalamic nucleus activity dynamics and limb movement prediction in Parkinson’s disease. Brain 143, 582–596. 
• Mosley, P.E., Paliwal, S., Robinson, K., Coyne, T., Silburn, P., Tittgemeyer, M., Stephan, K.E., Perry, A., Breakspear, M., 2020. The structural connectivity of subthalamic deep brain stimulation correlates with impulsivity in Parkinson’s. Brain.
• Nowacki, A., Schober, M., Nader, L., Saryyeva, A., Nguyen, T.‐A.K., Green, A.L., Pollo, C., Krauss, J.K., Fontaine, D. and Aziz, T.Z. (2020), Deep Brain Stimulation for Chronic Cluster Headache: Meta‐Analysis of Individual Patient Data. Ann Neurol.
• Shen, L., Jiang, C., Hubbard, C.S., Ren, J., He, C., Wang, D., Dahmani, L., Guo, Y., Liu, Y., Xu, S., Meng, F., Zhang, J., Liu, H. and Li, L. (2020), Subthalamic nucleus deep brain stimulation modulates two distinct neurocircuits. Ann Neurol. Accepted Author Manuscript.
• Irmen, F., Horn, A., Mosley, P., Perry, A., Petry‐Schmelzer, J.N., Dafsari, H.S., Barbe, M., Visser‐Vandewalle, V., Schneider, G., Li, N., Kübler, D., Wenzel, G., Kühn, A.A., 2020. Left Prefrontal Connectivity Links Subthalamic Stimulation with Depressive Symptoms. Ann. Neurol. 87, 962–975.
• Ren, L., Yu, T., Wang, D., Wang, X., Ni, D., Zhang, G., Bartolomei, F., Wang, Y., Li, Y., 2020. Subthalamic Nucleus Stimulation Modulates Motor Epileptic Activity in Humans. Ann. Neurol. ana.25776.
• Wong, J. K., Hess, C. W., Almeida, L., Middlebrooks, E. H., Christou, E. A., Patrick, E. E., et al. (2020). Deep brain stimulation in essential tremor: targets, technology, and a comprehensive review of clinical outcomes. Expert Review of Neurotherapeutics, 6, 1–13.
• Kringelbach, M.L., Cruzat, J., Cabral, J., Knudsen, G.M., Carhart-Harris, R., Whybrow, P.C., Logothetis, N.K., Deco, G., 2020. Dynamic coupling of whole-brain neuronal and neurotransmitter systems. Proc. Natl. Acad. Sci.
• Hamani, C., Davidson, B., Levitt, A., Meng, Y., Corchs, F., Abrahao, A., Rabin, J.S., Giacobbe, P., Lipsman, N., 2020. Patient With Posttraumatic Stress Disorder Successfully Treated With Deep Brain Stimulation of the Medial Prefrontal Cortex and Uncinate Fasciculus. Biol. Psychiatry
• Milosevic, L., Scherer, M., Cebi, I., Guggenberger, R., Machetanz, K., Naros, G., Weiss, D., Gharabaghi, A., 2020. Online Mapping with the Deep Brain Stimulation Lead: A Novel Targeting Tool in Parkinson’s Disease. Mov. Disord. mds.28093.
• Tsuboi, T., Charbel, M., Peterside, D.T., Rana, M., Elkouzi, A., Deeb, W., Ramirez‐Zamora, A., Lemos Melo Lobo Jofili Lopes, J., Almeida, L., Zeilman, P.R., Eisinger, R.S., Foote, K.D., Okromelidze, L., Grewal, S.S., Okun, M.S. and Middlebrooks, E.H. (2020), Pallidal Connectivity Profiling of Stimulation‐Induced Dyskinesia in Parkinson’s Disease. Mov Disord.
• Valsky D, Heiman Grosberg S, Israel Z, Boraud T, Bergman H, Deffains M. What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia? Elife. 2020;9.
• Boutet, A., Chow, C.T., Narang, K., Elias, G.J.B., Neudorfer, C., Germann, J., Ranjan, M., Loh, A., Martin, A.J., Kucharczyk, W., Steele, C.J., Hancu, I., Rezai, A.R., Lozano, A.M., 2020. Improving Safety of MRI in Patients with Deep Brain Stimulation Devices. Radiology
• Yue Chen, Chen Gong, Ye Tian, Natasza Orlov, Jianguo Zhang, Yi Guo, Shujun Xu, Changqing Jiang, Hongwei Hao, Wolf-Julian Neumann, Andrea A. Kühn, Hesheng Liu, Luming Li., 2020. Neuromodulation effects of deep brain stimulation on beta rhythm: A longitudinal local field potential study. Brain Stimulation.
• Wang, Q., Akram, H., Muthuraman, M., Gonzalez-Escamilla, G., Sheth, S.A., Oxenford, S., Yeh, F.-C., Groppa, S., Vanegas-Arroyave, N., Zrinzo, L., Li, N., Kühn, A., Horn, A., 2020. Normative vs. patient-specific brain connectivity in Deep Brain Stimulation. Neuroimage 117307
• Treu, S., Strange, B., Oxenford, S., Neumann, W.-J., Kühn, A., Li, N., Horn, A., 2020. Deep Brain Stimulation: Imaging on a group level. Neuroimage 117018.
• Smith, E.E., Schüller, T., Huys, D., Baldermann, J.C., Andrade, P., Allen, J.J., Visser-Vandewalle, V., Ullsperger, M., Gruendler, T.O.J., Kuhn, J., 2020. A brief demonstration of frontostriatal connectivity in OCD patients with intracranial electrodes. Neuroimage 117138.
• Wiest, C., Tinkhauser, G., Pogosyan, A., Bange, M., Muthuraman, M., Groppa, S., Baig, F., Mostofi, A., Pereira, E.A., Tan, H., Brown, P., Torrecillos, F., 2020. Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson’s disease. Neurobiol. Dis. 105019.
• Wilkins, KB., Parker, JE., Bronte-Stewart, HM. (2020). Gait variability is linked to the atrophy of the Nucleus Basalis of Meynert and is resistant to STN DBS in Parkinson’s Disease. Neurobiol. Dis. 105134.
• Lin, H., Na, P., Zhang, D., Liu, J., Cai, X., & Li, W. (2020). Brain connectivity markers for the identification of effective contacts in subthalamic nucleus deep brain stimulation. Human Brain Mapping, 2(1), 22–9.
• Alhourani, A., Korzeniewska, A., Wozny, T.A., Lipski, W.J., Kondylis, E.D., Ghuman, A.S., Crone, N.E., Crammond, D.J., Turner, R.S., Richardson, R.M., 2020. Subthalamic Nucleus Activity Influences Sensory and Motor Cortex during Force Transduction. Cereb. Cortex.
• Warren, A. E. L., Dalic, L. J., Thevathasan, W., Roten, A., Bulluss, K. J., & Archer, J. (2020). Targeting the centromedian thalamic nucleus for deep brain stimulation. Journal of Neurology, Neurosurgery, and Psychiatry, jnnp–2019–322030–11.
• Gratwicke, J., Oswal, A., Akram, H., Jahanshahi, M., Hariz, M., Zrinzo, L., Foltynie, T., Litvak, V., 2020. Resting state activity and connectivity of the nucleus basalis of Meynert and globus pallidus in Lewy body dementia and Parkinson’s disease dementia. Neuroimage 117184.
• Krause, P., Völzmann, S., Ewert, S., Kupsch, A., Schneider, G.H., Kühn, A.A., 2020. Long-term effects of bilateral pallidal deep brain stimulation in dystonia: a follow-up between 8 and 16 years. J. Neurol.
• Ahmed Jorge, PhD, Christina Dastolfo-Hromack, MS, Witold J Lipski, PhD, Ian H Kratter, MD, PhD, Libby J Smith, DO, Jackie L Gartner-Schmidt, PhD, R Mark Richardson, MD, PhD, Anterior Sensorimotor Subthalamic Nucleus Stimulation Is Associated With Improved Voice Function, Neurosurgery.
• Guo, W., Koo, B.-B., Kim, J.-H., Bhadelia, R.A., Seo, D.-W., Hong, S.B., Joo, E.Y., Lee, S., Lee, J.-I., Cho, K.R., Shon, Y.-M., 2020. Defining the optimal target for anterior thalamic deep brain stimulation in patients with drug-refractory epilepsy. J. Neurosurg. 1, 1–10.
• Vogel, D., Shah, A., Coste, J., Lemaire, J.-J., Wårdell, K., Hemm, S., 2020. Anatomical Brain Structures Normalization for Deep Brain Stimulation in Movement Disorders. NeuroImage Clin.
• Okromelidze, L., Tsuboi, T., Eisinger, R.S., Burns, M.R., Charbel, M., Rana, M., Grewal, S.S., Lu, C.-Q., Almeida, L., Foote, K.D., Okun, M.S., Middlebrooks, E.H., 2020. Functional and Structural Connectivity Patterns Associated with Clinical Outcomes in Deep Brain Stimulation of the Globus Pallidus Internus for Generalized Dystonia. Am. J. Neuroradiol.
• Chaitanya, G., Romeo, A.K., Ilyas, A., Irannejad, A., Toth, E., Elsayed, G., Bentley, J.N., Riley, K.O., Pati, S., 2020. Robot-assisted stereoelectroencephalography exploration of the limbic thalamus in human focal epilepsy: implantation technique and complications in the first 24 patients. Neurosurg. Focus 48, E2.
• You, Z., Wu, Y.Y., Wu, R., Xu, Z., Wu, X., Wang, X., 2020. Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson’s disease for 1 year. CNS Neurosci. Ther. cns.13392.
• Lai, G., Langevin, J.-P., Koek, R.J., Krahl, S.E., Bari, A.A., Chen, J.W.Y., 2020. Acute Effects and the Dreamy State Evoked by Deep Brain Electrical Stimulation of the Amygdala: Associations of the Amygdala in Human Dreaming, Consciousness, Emotions, and Creativity. Front. Hum. Neurosci. 14, 61.
• Kakusa, B., Saluja, S., Dadey, D.Y.A., Barbosa, D.A.N., Gattas, S., Miller, K.J., Cowan, R.P., Kouyoumdjian, Z., Pouratian, N., Halpern, C.H., 2020. Electrophysiology and Structural Connectivity of the Posterior Hypothalamic Region: Much to Learn From a Rare Indication of Deep Brain Stimulation. Front. Hum. Neurosci. 14, 164.
• Stuart D Washington, Rakib U Rayhan, Richard Garner, Destie Provenzano, Kristina Zajur, Florencia Martinez Addiego, John W VanMeter, James N Baraniuk, Exercise alters brain activation in Gulf War Illness and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Brain Communications, Volume 2, Issue 2, 2020
• Sun, X., Huang, L., Pan, Y., Zhang, C., Wang, T., Li, H., Sun, B., Ding, J., Wu, Y., Li, D., 2020. Bilateral Posterior Subthalamic Area Deep Brain Stimulation for Essential Tremor: A Case Series. Front. Hum. Neurosci. 14, 16.
• Cury, R. G., Teixeira, M. J., Galhardoni, R., Silva, V., Iglesio, R., França, C., et al. (2020). Connectivity Patterns of Subthalamic Stimulation Influence Pain Outcomes in Parkinson’s Disease. Frontiers in Neurology, 11, 173–9.
• Ozturk, M., Telkes, I., Viswanathan, A., Jimenez-shahed, J., Tarakad, A., Kumar, S., Sheth, S.A., Ince, N.F., 2020. Randomized, double-blind assessment of LFP versus SUA guidance in STN-DBS lead implantation : A Pilot Study. Front. Neurosci.
• Andrade, P., Heiden, P., Hoevels, M., Schlamann, M., Baldermann, J.C., Huys, D., Visser-Vandewalle, V., 2020. Modulation of Fibers to Motor Cortex during Thalamic DBS in Tourette Patients Correlates with Tic Reduction. Brain Sci. 10, 302.
• Kokkinos, V., Urban, A., Sisterson, N. D., Li, N., Corson, D., & Richardson, R. M. (2020). Responsive Neurostimulation of the Thalamus Improves Seizure Control in Idiopathic Generalized Epilepsy: A Case Report. Neurosurgery. 
• Wang, X., Du, J., Wang, D., Xu, C., Ren, Z., Wang, Y., Li, Y., Yu, T., Ren, L., 2020. Long-term outcome of unilateral deep brain stimulation of the subthalamic nucleus for a patient with drug-resistant focal myoclonic seizure. Ann. Transl. Med. 8, 18.
• Toth, E., Chaitanya, G., Pizarro, D., Kumar, S.S., Ilyas, A., Romeo, A., 2019. Ictal recruitment of anterior nucleus of thalamus in human focal epilepsy. bioRxiv 1–43.
• Wang, D., Huang, Z., Ren, L., Liu, J., Wang, Xueyuan, Yu, T., Hu, M., Wang, Xueming, Du, J., Ni, D., Zhang, X., Gao, R., Qiao, L., Wang, Y., 2020. Amygdalar and hippocampal beta rhythm synchrony during human fear memory retrieval. Acta Neurochir. (Wien). 1–9. 
• Levi, V., Franzini, A., Rinaldo, S. et al. Globus pallidus internus activity during simultaneous bilateral microelectrode recordings in status dystonicus. Acta Neurochir (2020).
• Scheibe, F., Neumann, W., Lange, C., Scheel, M., Furth, C., Köhnlein, M., Mergenthaler, P., Schultze‐Amberger, J., Triebkorn, P., Ritter, P., Kühn, A.A., Meisel, A., 2020. Movement disorders after hypoxic brain injury following cardiac arrest in adults. Eur. J. Neurol.
• Chaitanya, G., Toth, E., Pizarro, D., Irannejad, A., Riley, K., Pati, S., 2020. Precision mapping of the epileptogenic network with low- and high-frequency stimulation of anterior nucleus of thalamus. Clin. Neurophysiol. 131, 2158–2167.
• Butenko K, Bahls C, Schröder M, Köhling R, van Rienen U (2020) OSS-DBS: Open-source simulation platform for deep brain stimulation with a comprehensive automated modeling. PLoS Comput Biol 16(7): e1008023.
• De Marco, R., Bhargava, D., Macerollo, A., Osman-Farah, J., 2020. Could ZI have a role in DBS for Parkinson’s Disease? An observational study to optimize DBS.
• Molina, R., Hass, C.J., Sowalsky, K., Schmitt, A.C., Opri, E., Roper, J.A., Martinez-Ramirez, D., Hess, C.W., Foote, K.D., Okun, M.S., Gunduz, A., 2020. Neurophysiological Correlates of Gait in the Human Basal Ganglia and the PPN Region in Parkinson’s Disease. Front. Hum. Neurosci. 14, 194.
• Bočková, M., Lamoš, M., Klimeš, P. et al. Suboptimal response to STN-DBS in Parkinson’s disease can be identified via reaction times in a motor cognitive paradigm. J Neural Transm (2020).
• Duarte-Batista, P., Coelho, M., Quintas, S., Levy, P., Castro Caldas, A., Gonçalves-Ferreira, A., Carvalho, H., Cattoni, M.B., 2020. Anterior Limb of Internal Capsule and Bed Nucleus of Stria Terminalis Stimulation for Gilles de la Tourette Syndrome with Obsessive-Compulsive Disorder in Adolescence: A Case of Success. Stereotact. Funct. Neurosurg. 1–9.
• Polanski, W.H., Zolal, A., Sitoci-Ficici, K.H., Hiepe, P., Schackert, G., Sobottka, S.B., 2020. Comparison of Automatic Segmentation Algorithms for the Subthalamic Nucleus. Stereotact. Funct. Neurosurg. 1–7.
• Zolal A, Polanski W, H, Klingelhoefer L, Kitzler H, H, Linn J, Podlesek D, Sitoci-Ficici K, H, Reichmann H, Leonhardt G, K, Schackert G, Sobottka S, B: Parcellation of the Subthalamic Nucleus in Parkinson’s Disease: A Retrospective Analysis of Atlas- and Diffusion-Based Methods. Stereotact Funct Neurosurg 2020.
• Dembek T, A, Asendorf A, L, Wirths J, Barbe M, T, Visser-Vandewalle V, Treuer H: Temporal Stability of Lead Orientation in Directional Deep Brain Stimulation. Stereotact Funct Neurosurg 2020.
• Saluja, S., Barbosa, D.A.N., Parker, J.J., Huang, Y., Jensen, M.R., Ngo, V., Santini, V.E., Pauly, K.B., Ghanouni, P., McNab, J.A., Halpern, C.H., 2020. Case Report on Deep Brain Stimulation Rescue After Suboptimal MR-Guided Focused Ultrasound Thalamotomy for Essential Tremor: A Tractography-Based Investigation. Front. Hum. Neurosci. 14.
• Stuart D Washington, Rakib U Rayhan, Richard Garner, Destie Provenzano, Kristina Zajur, Florencia Martinez Addiego, John W VanMeter, James N Baraniuk, Exercise alters brain activation in Gulf War Illness and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Brain Communications, Volume 2, Issue 2, 2020
• Vissani M, Isaias IU, Mazzoni A. Deep brain stimulation: a review of the open neural engineering challenges. J Neural Eng. Published online September 4, 2020. doi:10.1088/1741-2552/abb581
• Tambirajoo, K., Furlanetti, L., Samuel, M., Ashkan, K., 2020. Subthalamic Nucleus Deep Brain Stimulation in Post-Infarct Dystonia. Stereotact. Funct. Neurosurg. 1–13.
• Ouyang, J., Hao, Q., Zhu, R., Wu, G., Ding, H., Wang, D., Liu, R., 2020. Subthalamic Nucleus Deep Brain Stimulation in Primary Meige Syndrome: A 1‐Year Follow‐Up Study. Neuromodulation Technol. Neural Interface ner.13174.
• Wang, Y., Zhang, C., Zhang, Y., Gong, H., Li, J., Jin, H., Li, D., Liu, D., Sun, B., 2020. Habenula deep brain stimulation for intractable schizophrenia: a pilot study. Neurosurg. Focus
• Takashi Morishita, Yuki Sakai, Hitoshi Iida, Saki Yoshimura, Atsushi Ishii, Shinsuke Fujioka, Saori Tanaka, Tooru Inoue. Neuroanatomical Considerations for Optimizing Thalamic Deep Brain Stimulation in Tourette Syndrome. MedRxiv.

2019

• Petry-Schmelzer, JN., Krause, M., Dembek, T., Horn, A., Evans, J., Ashkan, K., Rizos, A., Silverdale, M., Schumacher, W,. Sack, C., Loehrer, P., Fink, G., Fonoff, E., Martinez-Martin, P., Antonini, A., Barbe, M., Visser-Vandewalle, V., Ray-Chaudhuri, K., Timmermann, L., Dafsari, H. (2019). Non-motor outcomes depend on location of neurostimulation in Parkinson’s disease. Brain.
• Al-Fatly, B., Ewert, S., Kübler, D., Kroneberg, D., Horn, A., & Kühn, A. A. (2019). Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor. Brain. Preprint here.
• Dembek, T. A., Roediger, J., Horn, A., Reker, P., Oehrn, C., Dafsari, H. S., et al. (2019). Probabilistic Sweetspots Predict Motor Outcome for DBS in Parkinson’s Disease. Annals of Neurology, ana.25567–35.
• Juan Carlos Baldermann, M. D., Corina Melzer, M. S., Alexandra Zapf, M. S., Sina Kohl, P. D., Lars Timmermann, P., Marc Tittgemeyer, P. D., et al. (2019). Connectivity profile predictive of effective deep brain stimulation in obsessive compulsive disorder. Biological Psychiatry, 1–35.
• Malekmohammadi, M., Price, C. M., Hudson, A. E., DiCesare, J. A. T., & Pouratian, N. (2019). Propofol-induced loss of consciousness is associated with a decrease in thalamocortical connectivity in humans. Brain, 31, 51–15. 
• Vissani M, Cordella R, Micera S, Eleopra R, Romito LM, Mazzoni A. Spatio-temporal structure of single neuron subthalamic activity identifies DBS target for anesthetized Tourette syndrome patients. J Neural Eng. 2019;16(6):066011. Published 2019 Oct 23. 
• de Almeida Marcelino, A. L., Horn, A., Krause, P., Kühn, A. A., & Neumann, W.-J. (2019). Subthalamic neuromodulation improves short-term motor learning in Parkinson’s disease. Brain, 28, 10687–9.
• Horn, A., Wenzel, G., Irmen, F., Hübl, J., Li, N., Neumann, W.-J., et al. (2019). Deep Brain Stimulation induced normalization of the human functional connectome in Parkinson’s Disease. Brain. Preprint here.
• Reich, M. M., Horn, A., Lange, F., Roothans, J., Paschen, S., Runge, J., et al. (2019). Probabilistic mapping of antidystonic effect of pallidal neurostimulation: multicentre imaging study. Brain.
• Horn A (2019), The impact of modern-day neuroimaging on the field of deep brain stimulation. Current Opinion Neurology.
• Rappel, P., Grosberg, S., Arkadir, D., Linetsky, E., Abu Snineh, M., Bick, A.S., Tamir, I., Valsky, D., Marmor, O., Abo Foul, Y., Peled, O., Gilad, M., Daudi, C., Ben‐Naim, S., Bergman, H., Israel, Z., Eitan, R., 2019. Theta‐alpha oscillations characterize emotional subregion in the human ventral subthalamic nucleus. Mov. Disord. mds.27910. 
• Bouthour, W., Béreau, M., Kibleur, A., Zacharia, A., Tomkova Chaoui, E., Fleury, V., Benis, D., Momjian, S., Bally, J., Lüscher, C., Krack, P., Burkhard, P.R., 2019. Dyskinesia‐inducing lead contacts optimize outcome of subthalamic stimulation in Parkinson’s disease. Mov. Disord. mds.27853.
• Boutet, A., Rashid, T., Hancu, I., Elias, G.J.B., Gramer, R.M., Germann, J., Dimarzio, M., Li, B., Paramanandam, V., Prasad, S., Ranjan, M., Coblentz, A., Gwun, D., Chow, C.T., Maciel, R., Soh, D., Fiveland, E., Hodaie, M., Kalia, S.K., Fasano, A., Kucharczyk, W., Pilitsis, J., Lozano, A.M., 2019. Functional MRI Safety and Artifacts during Deep Brain Stimulation: Experience in 102 Patients. Radiology 293, 174–183.
• Chrabaszcz, A., Neumann, W.J., Stretcu, O., Lipski, W.J., Bush, A., Dastolfo-Hromack, C.A., Wang, D., Crammond, D.J., Shaiman, S., Dickey, M.W., Holt, L.L., Turner, R.S., Fiez, J.A., Richardson, R.M., 2019. Subthalamic nucleus and sensorimotor cortex activity during speech production. J. Neurosci. 39, 2698–2708. 
• Boutet, A., Jain, M., Elias, G. J. B., Gramer, R., Germann, J., Davidson, B., et al. (2019). Network Basis of Seizures Induced by Deep Brain Stimulation: Literature Review and Connectivity Analysis. World Neurosurgery, 132, 314–320
• Avecillas-Chasin, J.M., Honey, C.R., 2019. Modulation of Nigrofugal and Pallidofugal Pathways in Deep Brain Stimulation for Parkinson Disease. Neurosurgery. 
• Kroneberg, D., S. Ewert, A. C. Meyer, and A. A. Kuhn. 2019. ‘Shorter pulse width reduces gait disturbances following deep brain stimulation for essential tremor’, J Neurol Neurosurg Psychiatry.
• Huys, D., S. Kohl, J. C. Baldermann, L. Timmermann, V. Sturm, V. Visser-Vandewalle, and J. Kuhn. 2019. ‘Open-label trial of anterior limb of internal capsule-nucleus accumbens deep brain stimulation for obsessive-compulsive disorder: insights gained’, J Neurol Neurosurg Psychiatry.
• Dembek, T. A., Hoevels, M., Hellerbach, A., Horn, A., Petry-Schmelzer, J. N., Borggrefe, J., et al. (2019). Directional DBS leads show large deviations from their intended implantation orientation. Parkinsonism & Related Disorders. Preprint here.
• Huebl, J., A. Poshtiban, C. Brucke, S. Siegert, A. Bock, H. Koziara, T. Kmiec, R. Rola, T. Mandat, and A. A. Kuhn. 2019. ‘Subthalamic and pallidal oscillatory activity in patients with Neurodegeneration with Brain Iron Accumulation type I (NBIA-I)’, Clin Neurophysiol, 130: 469-73.
• Chen C-C, Yeh C-H, Chan H-L, et al. Subthalamic nucleus oscillations correlate with vulnerability to freezing of gait in patients with Parkinson’s disease. Neurobiol Dis. September 2019:104605. doi:10.1016/j.nbd.2019.104605
• Baldermann, J.C.; Bohn, K.P.; Hammes, J.; Schüller, C.B.; Visser-Vandewalle, V.; Drzezga, A.; Kuhn, J. Local and Global Changes in Brain Metabolism during Deep Brain Stimulation for Obsessive-Compulsive Disorder. Brain Sci. 2019, 9, 220.
• Luo H, Huang Y, Xiao X, et al. Functional dynamics of thalamic local field potentials correlate with modulation of neuropathic pain. Eur J Neurosci. September 2019:ejn.14569. doi:10.1111/ejn.14569
• Hancu, I., Boutet, A., Fiveland, E., Ranjan, M., Prusik, J., Dimarzio, M., et al. (2018). On the (Non‐)equivalency of monopolar and bipolar settings for deep brain stimulation fMRI studies of Parkinson’s disease patients. Journal of Magnetic Resonance Imaging : JMRI, 9(16), 219.
• Tinkhauser, G., Syed Shah, A., Fischer, P., Peterman, K., Debove, I., Nygyuen, K., Nowacki, A., Torrecillos, F., Khawaldeh, S., Tan, H., Pogosyan, A., Schuepbach, M., Pollo, C., Brown, P., 2019. Electrophysiological differences between Upper and Lower Limb movements in the human subthalamic nucleus. Clin. Neurophysiol. https://doi.org/10.1016/J.CLINPH.2019.02.011
• Avecillas Chasin, J. M., Poologaindran, A., Morrison, M. D., Rammage, L. A., & Honey, C. R. (2019). Unilateral Thalamic Deep Brain Stimulation for Voice Tremor. Stereotactic and Functional Neurosurgery, 1–8.
• Chunhui Yang, Yiqing Qiu, Xi Wu, Jiali Wang, Yina Wu, and Xiaowu Hu, “Analysis of Contact Position for Subthalamic Nucleus Deep Brain Stimulation-Induced Hyperhidrosis,” Parkinson’s Disease, vol. 2019, Article ID 8180123, 6 pages, 2019.
• Liu, F. T., L. Q. Lang, R. Y. Zhou, R. Feng, J. Hu, J. Wang, and J. J. Wu. 2019. ‘Urinary incontinence following deep brain stimulation of the globus pallidus internus: case report’, J Neurosurg: 1-3.
• Mei S, Li J, Middlebrooks EH, Almeida L, Hu W, Zhang Y, Ramirez-Zamora A and Chan P (2019) New Onset On-Medication Freezing of Gait After STN-DBS in Parkinson’s Disease. Front. Neurol. 10:659. doi: 10.3389/fneur.2019.00659
• Levi, V., Cordella, R., D’Ammando, A., Tringali, G., Dones, I., Messina, G., & Franzini, A. (2019). Dorsal anterior cingulate cortex (ACC) deep brain stimulation (DBS): a promising surgical option for the treatment of refractory thalamic pain syndrome (TPS), 1–10.
• Nguyen, T. A. K., Nowacki, A., Debove, I., Petermann, K., Tinkhauser, G., Wiest, R., et al. (2019). Directional stimulation of subthalamic nucleus sweet spot predicts clinical efficacy: Proof of concept. Brain Stimulation, 1–8.
• Elias, G.J.B., Giacobbe, P., Boutet, A., Germann, J., Beyn, M.E., Gramer, R.M., Pancholi, A., Joel, S.E., Lozano, A.M., 2019. Probing the circuitry of panic with deep brain stimulation: Connectomic analysis and review of the literature. Brain Stimul.
• Yang, C., Qiu, Y., Wu, X., Wang, J., Wu, Y., Hu, X., 2019. Analysis of contact position for subthalamic nucleus deep brain stimulation-induced hyperhidrosis. Parkinsons. Dis. 2019. 
• Zhang, D., Lin, H., Liu, J., Liu, Z., Yan, J., & Cai, X. (2019). Electrode Reconstruction Assists Postoperative Contact Selection in Deep Brain Stimulation. World Neurosurgery, 125, 1–6.
• Wang, Y.-C., Grewal, S. S., Middlebrooks, E. H., Worrell, G. A., Stead, M., Lundstrom, B. N., et al. (2019). Targeting analysis of a novel parietal approach for deep brain stimulation of the anterior nucleus of the thalamus for epilepsy. Epilepsy Research, 153, 1–6.
• Prent, N., Potters, W. V., Boon, L. I., Caan, M. W. A., de Bie, R. M. A., van den Munckhof, P., et al. (2019). Distance to white matter tracts is associated with deep brain stimulation motor outcome in Parkinson’s disease. Journal of Neurosurgery, 349, 1–10.
• Richard, A., Hsu, J., Baum, P., Alterman, R., Simon, D.K., 2019. Efficacy of Deep Brain Stimulation in a Patient with Genetically Confirmed Chorea-Acanthocytosis. Case Rep. Neurol. 11, 199–204. https://doi.org/10.1159/000500951

2018

• Neumann, W.-J., Schroll, H., de Almeida Marcelino, A. L., Horn, A., Ewert, S., Irmen, F., et al. (2018). Functional segregation of basal ganglia pathways in Parkinson’s disease. Brain, 12(Pt 1), 366.
• Neumann, W.-J., Huebl, J., Brücke, C., Lofredi, R., Horn, A., Saryyeva, A., et al. (2018). Pallidal and thalamic neural oscillatory patterns in Tourette syndrome. Annals of Neurology.
• Joutsa, J., Shih, L. C., Horn, A., Reich, M. M., Wu, O., Rost, N. S., & Fox, M. D. (2018). Identifying therapeutic targets from spontaneous beneficial brain lesions. Annals of Neurology.
• Joutsa, J., Horn, A., Hsu, J., & Fox, M. D. (2018). Localizing parkinsonism based on focal brain lesions. Brain : a Journal of Neurology, 141(8), 2445–2456. 
• Lofredi, R., Neumann, W.-J., Bock, A., Horn, A., Huebl, J., Siegert, S., et al. (2018). Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease. eLife, 7, e31895.
• Hell, F., Taylor, P. C. J., Mehrkens, J. H., & Bötzel, K. (2018). Subthalamic stimulation, oscillatory activity and connectivity reveal functional role of STN and network mechanisms during decision making under conflict. NeuroImage.
• Schroll, H., Horn, A., Runge, J., Lipp, A., Schneider, G.-H., Krauss, J. K., et al. (2018). Reinforcement magnitudes modulate subthalamic beta band activity in patients with Parkinson’s disease. Scientific Reports, 8(1), 8621.
• Irmen, F., Horn, A., Meder, D., Neumann, W.-J., Plettig, P., Schneider, G.-H., et al. (2018). Sensorimotor subthalamic stimulation restores risk-reward trade-off in Parkinson’s disease. Movement Disorders, 368(Suppl C), 610–11.
• Lofredi, R., Neumann, W.-J., Brücke, C., Huebl, J., Krauss, J. K., Schneider, G.-H., & Kühn, A. A. (2018). Pallidal beta bursts in Parkinson’s disease and dystonia. Movement Disorders, 126(12), 2597.
• Darrin J Lee, M. P., Robert F Dallapiazza, M. P., Philippe De Vloo, M. P., Gavin J B Elias, B. A., Anton Fomenko, M. D., Alexandre Boutet, M. D., et al. (2018). Inferior thalamic peduncle deep brain stimulation for treatment-refractory obsessive-compulsive disorder: a phase 1 pilot trial. Brain Stimulation, 1–40.
• Martínez-Fernández, R., Kibleur, A., Chabardes, S., Fraix, V., Castrioto, A., Lhommée, E., et al. (2018). Different effects of levodopa and subthalamic stimulation on emotional conflict in Parkinson’s disease. Human Brain Mapping, 35(1), 5083–14.
• Nowacki, A., Nguyen, T. A.-K., Tinkhauser, G., Petermann, K., Debove, I., Wiest, R., & Pollo, C. (2018). Accuracy of different three-dimensional subcortical human brain atlases for DBS -lead localisation. NeuroImage. Clinical, 20, 868–874.
• Middlebrooks, E. H., Tuna, I. S., Almeida, L., Grewal, S. S., Wong, J., Heckman, M. G., et al. (2018). Structural connectivity–based segmentation of the thalamus and prediction of tremor improvement following thalamic deep brain stimulation of the ventral intermediate nucleus. NeuroImage. Clinical.
• Hell, F., Plate, A., Mehrkens, J. H., & Bötzel, K. (2018). Subthalamic oscillatory activity and connectivity during gait in Parkinson’s disease. NeuroImage. Clinical, 19, 396–405.
• Yao, C., Horn, A., Li, N.-F., Lu, Y., Fu, Z.-H., Wang, N., et al. (2018). Post-operative electrode location and clinical efficacy of subthalamic nucleus deep brain stimulation in Meige syndrome. Parkinsonism & Related Disorders.
• Franco, R. R., Fonoff, E. T., Alvarenga, P. G., Alho, E. J. L., Lopes, A. C., Hoexter, M. Q., et al. (2018). Assessment of Safety and Outcome of Lateral Hypothalamic Deep Brain Stimulation for Obesity in a Small Series of Patients With Prader-Willi Syndrome.JAMA Network Open, 1(7), e185275–e185275.
• Lizarraga, K. J., Naghibzadeh, M., Boutet, A., Elias, G. J. B., & Fasano, A. (2018). Management of Pisa syndrome with lateralized subthalamic stimulation. Journal of Neurology, 265(10), 2442–2444.
• Lin, H., Cai, X.-D., Zhang, D.-D., Liu, J.-L., & Li, W.-P. (2018). Both DBS and Thalamotomy in a 13-year-old Patient with Primary Dystonia: A Case Report. World Neurosurgery.
• Middlebrooks, E. H., Grewal, S. S., Stead, M., Lundstrom, B. N., Worrell, G. A., & Van Gompel, J. J. (2018). Differences in functional connectivity profiles as a predictor of response to anterior thalamic nucleus deep brain stimulation for epilepsy: a hypothesis for the mechanism of action and a potential biomarker for outcomes. Neurosurgical Focus, 45(2), E7.
• Grewal, S. S., Middlebrooks, E. H., Kaufmann, T. J., Stead, M., Lundstrom, B. N., Worrell, G. A., et al. (2018). Fast gray matter acquisition T1 inversion recovery MRI to delineate the mammillothalamic tract for preoperative direct targeting of the anterior nucleus of the thalamus for deep brain stimulation in epilepsy. Neurosurgical Focus, 45(2), E6.
• Middlebrooks, E. H., Tuna, I. S., Grewal, S. S., Almeida, L., Heckman, M. G., Lesser, E. R., et al. (2018). Segmentation of the Globus Pallidus Internus Using Probabilistic Diffusion Tractography for Deep Brain Stimulation Targeting in Parkinson Disease. AJNR Am J Neuroradiol, 107, 64–8.
• Mosley, P. E., Smith, D., Coyne, T., Silburn, P., Breakspear, M., & Perry, A. (2018). The site of stimulation moderates neuropsychiatric symptoms after subthalamic deep brain stimulation for Parkinson’s disease. NeuroImage. Clinical.
• Mosley, P. E., Marsh, R., Perry, A., Coyne, T., & Silburn, P. (2018). Persistence of Mania After Cessation of Stimulation Following Subthalamic Deep Brain Stimulation. The Journal of Neuropsychiatry and Clinical Neurosciences, appi.neuropsych.
• Peisker, C., Schüller, T., Peters, J., Wagner, B., Schilbach, L., Müller, U., et al. (2018). Nucleus Accumbens Deep Brain Stimulation in Patients with Substance Use Disorders and Delay Discounting. Brain Sciences, 8(2), 21–15.
• Geng, X., Xu, X., Horn, A., Li, N., Ling, Z., Brown, P., & Wang, S. (2018). Intra-operative characterisation of subthalamic oscillations in Parkinson’s disease. Clinical Neurophysiology, 0(0).

2017

• Horn, A., Reich, M., Vorwerk, J., Li, N., Wenzel, G., Fang, Q., et al. (2017). Connectivity predicts deep brain stimulation outcome in Parkinson’s disease. Annals of Neurology.
• Neumann W-J*, Horn A*, Ewert S, Huebl J, Brücke C, Slentz C, Schneider G-H, Kühn AA (2017) Local theta activity in the human internal pallidum correlates with dystonic symptoms in patients with cervical dystonia. Annals of Neurology.
• Accolla, E. A., Horn, A., Herrojo Ruiz, M., Neumann, W.-J., & Kühn, A. A. (2017). Reply: Oscillatory coupling of the subthalamic nucleus in obsessive compulsive disorder. Brain.
• Horn, A., Neumann, W.-J., Degen, K., Schneider, G.-H., & Kühn, A. A. (2017). Toward an electrophysiological “sweet spot” for deep brain stimulation in the subthalamic nucleus. Human Brain Mapping.
• Horn, A., Kühn, A. A., Merkl, A., Shih, L., Alterman, R., & Fox, M. (2017). Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space. NeuroImage.
• van Wijk, B. C. M., Pogosyan, A., Hariz, M. I., Akram, H., Foltynie, T., Limousin, P., et al. (2017). Localization of beta and high-frequency oscillations within the subthalamic nucleus region. NeuroImage. Clinical, 16, 175–183.
• Hohlefeld, F. U., Ewald, A., Ehlen, F., Tiedt, H. O., Horn, A., Kühn, A. A., et al. (2017). Neural correlates of lexical decisions in Parkinson’s disease revealed with multivariate extraction of cortico-subthalamic interactions. Clinical Neurophysiology.
• Ehlen, F., Vonberg, I., Tiedt, H. O., Horn, A., Fromm, O., Kühn, A. A., & Klostermann, F. (2017). Thalamic deep brain stimulation decelerates automatic lexical activation. Brain and Cognition.
• Merkl A, Aust S, Schneider G-H, Visser-Vandewalle V, Horn A, Kühn AA, Kuhn J, Bajbouj, M (2017) Deep Brain Stimulation of the Subcallosal Cingulate Gyrus in Patients with Treatment-Resistant Depression: a double-blinded randomized controlled study and long-term follow-up in eight patients. Journal of Affective Disorders.
• Kroneberg, D., Plettig, P., Schneider, G.-H., & Kühn, A. A. (2017). Motor Cortical Plasticity Relates to Symptom Severity and Clinical Benefit From Deep Brain Stimulation in Cervical Dystonia. Neuromodulation: Technology at the Neural Interface, 27, 1789.
• Baldermann JC, Hardenacke K, Hu X, Köster P, Horn A, Freund H-J, Zilles K, Sturm V, Visser-Vandewalle V, Jessen F, Maintz D, Kuhn J (2017) Neuroanatomical Characteristics Associated With Response to Deep Brain Stimulation of the Nucleus Basalis of Meynert for Alzheimer’s Disease. Neuromodulation.
• Neumann W-J, Staub-Bartelt F, Horn A, Schanda J, Schneider G-H, Brown P, Kühn AA (2017) Long term correlation of subthalamic beta band activity with motor impairment in patients with Parkinson’s disease. Clinical Neurophysiology.

2016

• Accolla, E. A., Herrojo Ruiz, M., Horn, A., Schneider, G. H., Schmitz-Hubsch, T., Kühn, A. A., & Draganski, B. (2016). Brain networks modulated by subthalamic nucleus deep brain stimulation. Brain.
• Horn A, Kipp L, Meola A, Kühn AA, Leithner C (2016) Stroke mimicking thalamotomy – cessation of tremor following ventrolateral thalamic ischemia. Neurology.
• Tiedt H O, Ehlen F, Krugel LK, Horn A, Kühn AA, Klostermann F (2016) Subcortical Roles in Lexical Task Processing: Inferences from Thalamic and Subthalamic Event-Related Potentials. Human Brain Mapping
• Baldermann, J. C., Kohl, S., Visser-Vandewalle, V., Klehr, M., Huys, D., & Kuhn, J. (2016). Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum Reproducibly Improves Symptoms of Body Dysmorphic Disorder. Brain Stimulation.

• Krause P, Lauritsch K, Lipp A, Horn A, Weschke B, Kupsch A, Kiening K, Schneider G-H, Kühn A (2016) Long-term results of deep brain stimulation in a cohort of eight children with isolated dystonia. Journal of Neurology.

• Ehlen F, Vonberg I, Tiedt H O, Horn A, Fromm O, Kühn AA, Klostermann F (2016) Thalamic Deep Brain Stimulation Decelerates Automatic Lexical Activation. Brain and Cognition.

• Neumann WJ, Staub F, Horn A, Schanda J, Schneider G-H, Brown P, Kühn AA (2016) Deep brain recordings using an implanted pulse generator in Parkinson’s disease. Neuromodulation.

• Fischer P, Ossandón JP, Keyser J, Gulberti A, Wilming N, Hamel W, Köppen J, Buhmann C, Westphal M, Gerloff C, Moll CKE, Engel AK, König P (2016). STN-DBS Reduces Saccadic Hypometria but Not Visuospatial Bias in Parkinson’s Disease Patients. Frontiers in Behavioral Neuroscience.
• Horn A, Neumann WJ, Kühn AA (2016). Forschung: Tiefe Hirnstimulation – Methodische Umbrüche. Deutsches Ärzteblatt.

2015

• Neumann WJ, Jha A, Bock A, Huebl J, Horn A, Schneider G-H, Sander TH, Litvak V, Kühn AA (2015) Cortico-pallidal oscillatory connectivity in patients with dystonia. Brain.
• Merkl A, Neumann W-J, Huebl J, Horn A, Kuhn J, Dziobek I, Schneider G-H, Bajbouj M, Kühn AA (2015) Modulation of beta band activity in the Subgenual Anterior Cingulate Cortex during emotional empathy in Treatment-Resistant Depression. Cerebral Cortex.
• Schroll H, Horn A, Huchzermeyer C, Brücke C, Lütjens G, Krauss J, Schneider G-H, Kühn A, Hamker F (2015) Differential contributions of the globus pallidus and ventral thalamus to stimulus-response learning in humans. NeuroImage.
• Hohlefeld F, Ehlen F, Tiedt HO, Krugel LK, Horn A, Kühn AA, Curio G, Klostermann F, Nikulin VV (2015) Correlation between cortical and subcortical neural dynamics on multiple time scales in Parkinson’s disease. Neuroscience.

• Krause P, Brüggemann N, Völzmann S, Horn A, Kupsch A, Schneider G-H, Klein C, Kühn A (2015) Long-term improvement of dystonia after pallidal Deep Brain Stimulation in three members of a DYT6 family. Journal of Neurology.

2014

• Barow E, Neumann W-J, Brücke C, Huebl J, Horn A, Brown P, Krauss JK, Schneider G-H, Kühn AA (2014) Deep brain stimulation suppresses pallidal low frequency activity in patients with phasic dystonic movements. Brain.

  

• Ruiz MH, Hong SB, Hennig H, Altenmüller E, Kühn AA (2014) Long-range correlation properties in timing of skilled piano performance: the influence of auditory feedback and deep brain stimulation. Frontiers in Psychology.

• Brücke C, Ebner S, Horn A, Gärtner J, Huppke P, Kupsch A, Schneider G-H, Kühn AA (2014) Failure of pallidal deep brain stimulation in a case of rapid-onset dystonia parkinsonism (DYT12). Movement Disorders – Clinical Practice.

Applications of Lead-Connectome

• Fox MD, Buckner RL, Liu H, Chakravarty MM, Lozano AM, Pascual-Leone A (2014) Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases. PNAS.
• Weigand A*, Horn A*, Caballero R, Cooke D, Stern AP, Taylor SF, Press D, Pascual-Leone A, Fox MD (2017) Prospective validation that subgenual connectivity predicts antidepressant efficacy of transcranial magnetic stimulation sites. Biological Psychiatry.
• Darby R, Horn A, Cushman F, Fox MD (2017) Lesion network localization of criminal behavior. PNAS.

• Horn, A., & Blankenburg, F. (2015). Towards a standardized structural-functional group connectome in MNI space. NeuroImage.

• Horn, A. (2015). A structural group-connectome in standard stereotactic (MNI) space. Data in Brief,

• Seo S, Mohr J, Li N, Horn A, Obermayer K (2015) Incremental Pairwise Clustering for Large Proximity Matrices. IJCNN 2015.

Did we miss a publication that used LEAD-DBS scientifically?