A question for Lead Connectome

[dargonchow1]

Dear developer

My research interest in focusing on using functional connectome as the surrogate marker in disease investigation. After using Lead Connectome, I think the default option is perform WM, CSF and global signal regression in functional connectome estimation. However, I wish to construct the functional connectome without global signal regression. Could you tell me how to disable the option of global signal regression in Lead Connectome.

Thank you

[andreashorn]

Hi there,

no, by default, the global signal is not regressed out (but it’s calculated).
https://github.com/leaddbs/leaddbs/blob/master/connectomics/ea_extract_timecourses.m#L193

As you can see, the according line is commented out – if instead you’d want to correct for the global signal, you could uncomment that line ^^.

Best, Andy

[Author]

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