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Dear developer
My research interest in focusing on using functional connectome as the surrogate marker in disease investigation. After using Lead Connectome, I think the default option is perform WM, CSF and global signal regression in functional connectome estimation. However, I wish to construct the functional connectome without global signal regression. Could you tell me how to disable the option of global signal regression in Lead Connectome.
Thank you
Hi there,
no, by default, the global signal is not regressed out (but it’s calculated).
https://github.com/leaddbs/leaddbs/blob/master/connectomics/ea_extract_timecourses.m#L193As you can see, the according line is commented out – if instead you’d want to correct for the global signal, you could uncomment that line ^^.
Best, Andy
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