The main focus of our work is deep brain stimulation (DBS) – predominantly in movement disorders such as Parkinson’s Disease, Essential Tremor or Dystonia – more rarely in cognitive disorders such as Depression or Alzheimer’s Disease. In DBS, electrodes are surgically implanted into deep (subcortical) areas of the brain and – using an implanted impulse generator – these structures are stimulated chronically. The figure below shows a reconstruction of two DBS leads implanted with target subthalamic nucleus (orange) to treat Parkinson’sDisease.
Building tools to reconstruct electrode placement
Since 2012, we develop an open-source toolbox to facilitate reconstruction of DBS electrode placement based on postoperative imaging.
Lead-DBS has since become a leading platform for DBS imaging research with specific focus on brain connectivity between DBS stimulation sites and other areas in the brain.
Based on publications in the field of brain connectomics, Lead-DBS was extended by a sister application Lead-Connectome to facilitate and integrate connectomic analyses. Since then, Lead-DBS is part of the Lead Neuroimaging Suite (leadsuite.io) which features a growing number of tools that could be interesting to researchers above and beyond the field of deep brain stimulation.