12/09/2019 at 11:48 AM #8837
Yes, you always need to run normalizations. However, that doesn’t mean they are actually used.
For prereconstruction, some of the algorithms need some waypoints that are defined in MNI space and then transformed to native space.
So again i) yes you will always need to run normalizations in Lead-DBS but ii) you can still use the native space reconstructions that do not really use the normalization and iii) if you use atlases in native space that are not manually reconstructed, the inverse of the normalization will be used.